Tenofovir is the fumarate salt, a nucleotide that becomes an active metabolite in the process of metabolism. It has an antiviral effect on the eight most common types of human immunodeficiency virus HIV-1 of several subtypes, namely subtypes A, C, D, E, F, G and O). Due to the intake of tenofovir, specific activity can be manifested regarding not only HIV-1 strains, but also HIV-2 strains. Also, the drug is effective in the treatment of hepatitis B. Tenofovir causes inhibition of reverse transcriptase and HBV polymerase, as well as the breakage of the DNA chain after attachment to it as a result of exposure and metabolic processes. It does not have mitochondrial toxicity.
This drug is intended to treat an infection that is caused by HIV-1 (human immunodeficiency virus-1). Concurrent use with other antiretroviral drugs is possible and even desirable.
Also, this drug is prescribed for the treatment of hepatitis B, in its chronic form.
- The medication in question is not used if the patient has ever had hypersensitivity (allergy) to one of the components that make it up.
- Do not use as well if the patient suffers from severe liver failure.
- In addition, it should not be used concurrently with such drugs as voriconazole, terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil, and ergot alkaloids (ergotamine, dihydroergotamine, ergonovine, and methyl ergonovine).
- Do not take together with any drugs that contain St. John’s wort or its particles in the form of an extract, alcoholic infusion, because Hypericum weakens the effect of this drug.
- Contraindicated use for the treatment of children and adolescents until the age of 18 years.
- Use during pregnancy and lactation
- This drug is contraindicated for the treatment of pregnant women.
- Lactation at the time of treatment with this drug is suspended.
Dosage and administration
The recommended dosing regimen of this drug: 1 tablet 1 time per day, at the same time of the day. Even a light meal significantly improves the effectiveness of the drug, because it should be taken during a meal. Elderly patients use with great care. During therapy should not take grapefruit juice due to the fact that the latter reduces the effectiveness of the drug.
Overdose of this drug is extremely cause increased side effects on the central nervous system, muscle cramps. In case of an accidental overdose, symptomatic treatment should be applied, measures should be taken to detoxify the patient – flush the stomach, take enterosorbents.
The use of this drug in a patient can cause side effects in the form of:
- neutropenia, anemia, hypophosphatemia, hyperglycemia, hypokalemia, lactic acidosis;
- Allergic reactions, itching, rash, allergic urticaria, eosinophilia, anaphylactic shock, angioedema;
- nightmares, anxiety, insomnia, drowsiness;
- suicidal thoughts and behavior, delusions of euphoria, aggression, neurosis;
- seizures, amnesia, ataxia, agitation, tremor;
- impaired vision and hearing, tides;
- nausea, vomiting, diarrhea, dyspepsia, flatulence, pancreatitis;
- hepatitis, liver and / or renal failure;
- muscle weakness, asthenia, myopathy, osteomalacia;
- nephritis, non-sugar renal diabetes.
Terms and conditions of storage
This drug retains its medicinal properties for 2 years, which are measured from the date of manufacture, which is indicated by the manufacturer. The drug should be kept out of the reach of children. Storage temperature should not exceed 30 ° C.